RT Journal
A1 Tang R, Wang J, Tsao K, Ho Y
T1 LYmphangiosis as a predictor of outcome in patients with primary diffusely infiltrative adenocarcinoma of the colon and rectum
JF Archives of Surgery
JO Archives of Surgery
YR 1999
FD February 1
VO 134
IS 2
SP 157
OP 160
DO 10.1001/archsurg.134.2.157
UL http://dx.doi.org/10.1001/archsurg.134.2.157
AB Objective 
    To investigate the relationships between outcome and clinicopathological factors, DNA flow cytometrical characteristics, and postoperative adjuvant therapy in patients with primary diffusely infiltrative colorectal adenocarcinoma.Design 
    Inception cohort study.Setting 
    A medical center that offers a mixture of primary, secondary, and tertiary care services.Patients 
    Among 7035 patients undergoing resection of primary colorectal adenocarcinoma from 1980 to 1996, 37 patients with a pathological diagnosis of primary diffusely infiltrative tumor were selected. All patients had received regular follow-up until February 28, 1998, or until death.Main Outcome Measures 
    Cancer-specific survival compared by log-rank test and Cox regression model.Results 
    Univariate analyses revealed tumor stage (stages II-III vs stage IV, P=.01) and severity of lymphangiosis (absent/mild vs moderate/severe, P=.04) were significant in predicting outcome. A proliferative index of greater than 20% was insignificant (P=.08) in predicting outcome. In a Cox regression model, TNM stage and lymphangiosis were independently correlated with a worse outcome. When compared with tumors having less severe lymphangiosis, the odds ratio of death due to cancer in cases of tumors with moderate to severe lymphangiosis was 2.4 (95% confidence interval, 1.0-5.6; P=.05).Conclusion 
    Lymphangiosis and TNM stage were independently predictive of outcome in patients with primary diffusely infiltrative colorectal cancer.