RT Journal
A1 Ward PA, Lentsch AB
T1 THe acute inflammatory response and its regulation
JF Archives of Surgery
JO Archives of Surgery
YR 1999
FD June 1
VO 134
IS 6
SP 666
OP 669
DO 10.1001/archsurg.134.6.666
UL http://dx.doi.org/10.1001/archsurg.134.6.666
AB The acute inflammatory response is composed of an elaborate cascade of both proinflammatory and anti-inflammatory mediators. The balance between these mediators often determines the outcome after injury. In clincal scenarios, such as trauma or sepsis, there is often unregulated production of proinflammatory mediators that can cause multiple organ failure. Further understanding of the endogenous mechanisms that control the inflammatory response is needed to facilitate development of therapeutic options. In this review, we discuss the current knowledge of the mechanisms leading to development of acute inflammatory injury as well as the factors that regulate this response.