RT Journal
A1 Tzianabos AO, Cisneros RL, Gershkovich J, et al
T1 EFfect of surgical adhesion reduction devices on the propagation of experimental intra-abdominal infection
JF Archives of Surgery
JO Archives of Surgery
YR 1999
FD November 1
VO 134
IS 11
SP 1254
OP 1259
DO 10.1001/archsurg.134.11.1254
UL http://dx.doi.org/10.1001/archsurg.134.11.1254
AB Hypothesis 
    The use of certain surgical adhesion reduction devices where there is a risk of concomitant bacterial contamination potentiates intra-abdominal infection.Design 
    Evaluation of adhesion reduction devices in an experimental model of intra-abdominal infection.Setting 
    Experimental animal model.Interventions 
    Adhesion reduction devices were administered at the time of bacterial challenge.Main Outcome Measures 
    Animal mortality rate, abscess formation, and bacterial counts in peritoneal fluid and blood cultures.Results 
    The use of bioresorbable membrane adhesion reduction devices in the presence or absence of antibiotic therapy did not alter the disease process as compared with appropriate control groups. However, adhesion reduction gels prepared from sodium hyaluronate and carboxymethylcellulose chemically modified with carbodiimide or ferric ion complexed sodium hyaluronate increased the incidence of peritonitis in treated animals. Gel formulations containing diimide-modified carboxymethylcellulose did not have this effect.Conclusions 
    The use of certain adhesion reduction devices resulted in the propagation of intra-abdominal infection in an experimental rat model. This outcome was dependent on the composition of the device employed. The use of adhesion reduction devices should be tested in appropriate models of infection where there is the risk of concomitant bacterial contamination.