RT Journal A1 Martin JD T1 A glass half full JF Archives of Surgery JO Archives of Surgery YR 2003 FD February 1 VO 138 IS 2 SP 227 OP 227 DO 10.1001/archsurg.138.2.227-a UL http://dx.doi.org/10.1001/archsurg.138.2.227-a AB We have been extremely enthusiastic about the effectiveness of CoSeal in sealing surgical anastomoses and believe that this attribute represents a significant improvement in controlling suture line bleeding. Dr Victorino notes that the time savings were not significant enough to warrant the use of CoSeal; however, we believe that the data suggest the contrary. There was a significant improvement in sealing anastomoses in this unselected population, and the differences would likely be even greater if the patients selected were only those at high risk for bleeding problems (patients requiring perioperative anti-coagulation or those receiving clopidogrel bisulfate). Selective use of CoSeal more appropriately represents our clinical practice, and in the right patient, rapid access to a reliable sealant is invaluable.