RT Journal
A1 Zimmerman MA, Selzman CH, Cothren C, Sorensen AC, Raeburn CD, Harken AH
T1 DIagnostic implications of c-reactive protein
JF Archives of Surgery
JO Archives of Surgery
YR 2003
FD February 1
VO 138
IS 2
SP 220
OP 224
DO 10.1001/archsurg.138.2.220
UL http://dx.doi.org/10.1001/archsurg.138.2.220
AB An elevated level of C-reactive protein (CRP), an acute phase protein, is one of many downstream indicators of inflammation. Physiologically, CRP enhances cell-mediated immunity by promoting phagocytosis, accelerating chemotaxis, and activating platelets. The purposes of this article are (1) to review the clinical data implicating serum CRP level as a systemic marker of focal inflammation and (2) to explore serum CRP level as a reflection of the inflammatory component of atherogenesis. Our findings indicate that CRP levels serve as an early marker of the magnitude of inflammation in events as dissimilar as appendicitis and myocardial infarction. The level of circulating CRP correlates with endovascular disease and may serve to identify otherwise asymptomatic patients at sufficient cardiovascular risk to warrant aggressive therapy. Determining whether CRP has a direct pathologic role in the vascular wall itself may have the most clinical relevance.