RT Journal
A1 Yang GP, Longaker MT
T1 HYperbaric oxygen for treating wounds—invited critique
JF Archives of Surgery
JO Archives of Surgery
YR 2003
FD March 1
VO 138
IS 3
SP 280
OP 280
DO 10.1001/archsurg.138.3.280
UL http://dx.doi.org/10.1001/archsurg.138.3.280
AB 
This study highlights an important point in the translation of basic scientific knowledge to actual bedside treatment. A number of in vitro studies have indicated that cells involved in the process of wound repair are dysfunctional when placed in a hypoxic environment. The direct translation of these data was that oxygen delivery to poorly healing wounds was compromised and that improved oxygen delivery might allow those wounds to heal. An added corollary is that in a disease process where a lack of oxygen is required for progression, ie, necrotizing infections, the use of HBO might limit spread and aid recovery. However, Wang et al has clearly demonstrated that there are no clear guidelines for HBO therapy.