RT Journal
A1 Müller SA, Treutner KH, Haase G, Kinzel S, Tietze L, Schumpelick V
T1 EFfect of intraperitoneal antiadhesive fluids in a rat peritonitis model
JF Archives of Surgery
JO Archives of Surgery
YR 2003
FD March 1
VO 138
IS 3
SP 286
OP 290
DO 10.1001/archsurg.138.3.286
UL http://dx.doi.org/10.1001/archsurg.138.3.286
AB Hypothesis 
    Phospholipids and icodextrin reduce peritoneal adhesions resulting from general peritonitis without promoting abscess formation.Design 
    Evaluation of adhesion reduction fluids in a randomized animal study using a standardized peritonitis model.Setting 
    Experimental animal model in a university laboratory.Interventions 
    In 60 rats, experimental peritonitis was induced using the cecal ligation and puncture model. On day 1, the abdominal cavity was rinsed with 10 mL of isotonic sodium chloride solution and the cecum was resected. Animals were randomly assigned to 3 groups: the RL group, which received Ringer lactate intraperitoneally; the PL group, which received phospholipids intraperitoneally; and the ID group, which received icodextrin intraperitoneally. In each group, 50% of the animals were humanely killed at day 11 and 50% at day 21.Main Outcome Measures 
    The areas of adhesions were measured and the abscess formation was scored according to location and size. Abscesses, abdominal fluid, and blood were sampled for microbiologic workup.Results 
    The median area of adhesions was significantly lower in the PL groups (PL11, 43.7 mm2; PL21, 20.4 mm2) than in the RL groups (RL11, 163.8 mm2; RL21, 120.9 mm2) and ID groups (ID11, 418.5 mm2; ID21, 218.6 mm2). Abscess formation was increased by icodextrin but not influenced by phospholipids, whereas microbiologic investigations did not reveal any differences among these 3 groups.Conclusions 
    In this model of general peritonitis, phospholipids significantly reduced adhesion formation without promoting septic complications. Icodextrin enhanced adhesion and abscess formation in this peritonitis model. Phospholipids may be beneficial for adhesion control in general peritonitis.