RT Journal
A1 Imamura H, Seyama Y, Kokudo N, et al
T1 ONe thousand fifty-six hepatectomies without mortality in 8 years
JF Archives of Surgery
JO Archives of Surgery
YR 2003
FD November 1
VO 138
IS 11
SP 1198
OP 1206
DO 10.1001/archsurg.138.11.1198
UL http://dx.doi.org/10.1001/archsurg.138.11.1198
AB Background 
    Despite improvements in diagnostic and surgical techniques, operative mortality associated with liver resection is still greater than 2% in most of the recent studies.Hypothesis 
    By refining preoperative and postoperative care and surgical skills, liver resection mortality can be decreased to zero.Design 
    Retrospective cohort study to analyze postoperative morbidity and mortality in 1056 consecutive hepatectomies performed at a single medical center during 8 years.Setting 
    Tertiary referral center.Patients 
    A total of 915 patients who underwent 1056 consecutive hepatic resections: 532 for hepatocellular carcinoma, 262 for other primary and secondary liver malignancies, 57 for biliary tract malignancy, 174 for living donor liver transplantation, and 31 for other benign diseases.Main Outcome Measures 
    Operative mortality and morbidity rates.Results 
    No operative mortality occurred. Major complications, as defined by postoperative radiologic or surgical intervention, occurred in 3% of patients with hepatocellular carcinoma, 8% with other liver malignancy, 28% with biliary malignancy, and 5% of living donor liver transplantation donors. Using multiple logistic regression, independent risk factors associated with major complications were operative blood loss of 1000 mL or greater for hepatocellular carcinoma and total bilirubin level of 1.0 mg/dL or greater (≥17 µmol/L) and operative time greater than 6 hours for other liver malignancy. No independent factors associated with major complications were identified for biliary malignancy or for living donor liver transplantation donors among the variables investigated in this study.Conclusions 
    Liver resection can be performed without mortality provided that it is carried out in a high-volume medical center by well-trained hepatobiliary surgeons paying meticulous attention to the balance between the liver functional reserve and the volume of liver to be removed.