RT Journal
A1 Nilsson KR, Berenholtz SM, Garrett-Mayer E, Dorman T, Klag MJ, Pronovost PJ
T1 ASsociation between venous thromboembolism and perioperative allogeneic transfusion
JF Archives of Surgery
JO Archives of Surgery
YR 2007
FD February 1
VO 142
IS 2
SP 126
OP 132
DO 10.1001/archsurg.142.2.126
UL http://dx.doi.org/10.1001/archsurg.142.2.126
AB Hypothesis 
    Perioperative allogeneic blood product transfusion would be associated with venous thromboembolic complications in surgical patients.Design 
    Observational study using a state discharge database.Setting 
    Nonfederal acute care hospitals in Maryland performing colorectal cancer resections between January 1, 1994, and December 31, 2000.Patients 
    We obtained data on 14 014 adult patients having a primary diagnosis code for colorectal cancer and a primary procedure code for colorectal resection.Main Outcome Measures 
    The primary outcome variable was a discharge diagnosis of venous thromboembolism (VTE).Results 
    Venous thromboembolism occurred in 1% of patients and was associated with an adjusted 3.8-fold increase in mortality (odds ratio, 3.8; 95% confidence interval, 2.1-6.8), a 61% increase in mean hospital length of stay, and a 72% increase in mean total hospital charges. Risk factors for VTE after adjustment included transfusion, female sex, age 80 years or older, moderate to severe liver disease vs no liver disease, admission through the emergency department, and low annual surgeon case volume. Transfusion was associated with an increase in the odds of developing VTE in women (odds ratio, 1.8; 95% confidence interval, 1.2-2.6) but not in men (odds ratio, 0.9; 95% confidence interval, 0.5-1.9). In the absence of transfusion, female compared with male sex was not associated with an increased risk of VTE (odds ratio, 1.2; 95% confidence interval, 0.8-1.7).Conclusions 
    In this large observational study of patients undergoing colorectal cancer resection, perioperative allogeneic blood transfusion was associated with an increased risk of VTE in women but not in men. Given the substantial morbidity and mortality associated with VTE and the implication that this finding has for postoperative management in women, this association must be confirmed in independent studies.