RT Journal
A1 Scarpa M, Ruffolo C, Polese L, et al
T1 Quality of life after restorative proctocolectomy for ulcerative colitis: Different questionnaires lead to different interpretations
JF Archives of Surgery
JO Archives of Surgery
YR 2007
FD February 1
VO 142
IS 2
SP 158
OP 165
DO 10.1001/archsurg.142.2.158
UL http://dx.doi.org/10.1001/archsurg.142.2.158
AB Background 
    According to some researchers, health-related quality-of-life scores for patients who undergo restorative proctocolectomy (RPC) for ulcerative colitis (UC) are comparable to those of healthy control subjects. Other studies show evidence that patients who undergo RPC experience a health-related quality of life similar to patients with mild UC or UC in remission.Hypothesis 
    The discrepancy in health-related quality-of-life scores among studies may be due to different health-related quality-of-life analyses.Design 
    Cross-sectional study.Setting 
    Outpatient clinic of a tertiary care center.Patients 
    In the first phase of the study, we consecutively enrolled 24 patients with UC, 24 patients with Crohn disease, and 24 healthy controls. In the second phase of the study, 40 patients who underwent RPC, 43 patients with UC, and 44 controls were consecutively enrolled.Interventions 
    We administered an Italian version of the Cleveland Global Quality of Life (CGQL) instrument, the Padova Inflammatory Bowel Disease Quality of Life instrument, and the Italian 36-Item Short-Form Health Survey.Main Outcome Measures 
    We evaluated the construct validity, internal consistency, test-retest reliability, sensitivity to change, and discriminant ability of the Italian CGQL instrument. We compared its discriminative ability with that of the Padova Inflammatory Bowel Disease Quality of Life instrument.Results 
    The Italian CGQL instrument obtained good construct validity, internal consistency, test-retest reliability, and sensitivity to change. The Italian CGQL score did not distinguish patients who underwent RPC from healthy controls and those with mild UC or UC in remission, while the Padova Inflammatory Bowel Disease Quality of Life instrument reported similar scores for patients who underwent RPC and those with mild UC or UC in remission, and showed a difference vs healthy controls.Conclusions 
    We validated an Italian version of the CGQL score. The different results obtained with the CGQL and the Padova Inflammatory Bowel Disease Quality of Life instruments can be attributed to the different discriminative ability of the 2 questionnaires.