RT Journal A1 Harold KL, Huguet KL, Rush RM, Jr, et al T1 OPen or laparoscopic resection of a large gastric gastrointestinal stromal tumor—reply JF Archives of Surgery JO Archives of Surgery YR 2009 FD February 1 VO 144 IS 2 SP 193 OP 197 DO 10.1001/archsurg.2008.554 UL http://dx.doi.org/10.1001/archsurg.2008.554 AB Avoidance of tumor rupture is of utmost importance during GIST resection. Tumors in difficult locations can be manipulated by use of nontraumatic graspers on the stomach wall near the tumor, avoiding direct tumor manipulation. Alternatively, a stitch can be placed near the tumor in normal tissue for retraction. We will typically approach GIST tumors with invasion into adjacent organs through an open operation, though we may begin with diagnostic laparoscopy to confirm invasion that is suspected on preoperative imaging.