RT Journal
A1 WOODHALL B, GRAVES RW, BEARD JW
T1 EXperimental production of tumors of the brain with the shope rabbit papilloma
JF Archives of Surgery
JO Archives of Surgery
YR 1939
FD March 1
VO 38
IS 3
SP 457
OP 470
DO 10.1001/archsurg.1939.01200090062006
UL http://dx.doi.org/10.1001/archsurg.1939.01200090062006
AB Cutaneous papillomas developing in rabbits inoculated with the virus of infectious papillomatosis1 possess the characters of mammalian tumors2 and are readily susceptible to autotransplantation. Bits of hashed papilloma tissue implanted in muscle, subcutaneous tissue and inner organs of the host proliferate actively, invading or displacing adjacent tissue. In the absence of bacterial infection, cellular reaction about the growing implants is notably scanty; frequently none is present. Under these conditions the growth is a slowly enlarging mass which has little apparent effect on the surrounding tissues other than that attributable to pressure or to physical interference. This character of the transplanted papilloma has suggested its use in the study of the effects of pressure inside the cranial cavity. With this in mind, the behavior of the papilloma on implantation in various sites within the skulls of domestic rabbits has been studied. The results obtained are described in the present