RT Journal
A1 STATE D
T1 USe of human fibrin foam and thrombin solution as hemostatic agents in general surgery
JF Archives of Surgery
JO Archives of Surgery
YR 1949
FD March 1
VO 58
IS 3
SP 284
OP 290
DO 10.1001/archsurg.1949.01240030290005
UL http://dx.doi.org/10.1001/archsurg.1949.01240030290005
AB HEMOSTASIS always presents a major problem to the surgeon. Where bleeding is brisk, as from a severed artery or large vein, it is usually stopped immediately by the application of forceps and ligatures. Much more difficult to control is the constant oozing that results from injury to small venules and capillaries. If one measures loss of blood by the increment of gain in dry sponges,1 it becomes readily apparent that most of the loss of blood during the usual major surgical procedure is from the latter, rather than from the former, source of bleeding.Bleeding from brain, kidney, liver or vascular tumors is difficult to control by the application of forceps or clips because of the friability of the tissues. In an operative field where infection is present or has subsided (as in decortication of a lung), the bleeding from the friable and tough fibrous tissue is most difficult