RT Journal
A1 KOVE S, GOLDSTEIN S, PERRY RE, WRÓBLEWSKI F
T1 DIagnosis of neonatal jaundice by serum transaminase
JF A.M.A. Archives of Surgery
JO A.M.A. Archives of Surgery
YR 1959
FD January 1
VO 78
IS 1
SP 157
OP 168
DO 10.1001/archsurg.1959.04320010159026
UL http://dx.doi.org/10.1001/archsurg.1959.04320010159026
AB Problem of Neonatal Jaundice 
    Icterus of unknown origin in the neonatal period frequently presents a difficult problem in diagnosis. For this time of life the history, physical examination, and available laboratory techniques are often of limited value in supplying adequate information from which a correct etiologic diagnosis may be made.Early diagnosis is of importance so that proper definitive therapy may be instituted with the least possible delay. Thereby, in medical types of neonatal icterus unnecessary and harmful surgical exploration may be avoided, and in surgical types of neonatal icterus pathological sequelae may be limited by prompt operative intervention.Differential Diagnosis of Neonatal Jaundice 
    Neonatal jaundice may be caused by a number of conditions, from benign to serious:1. Physiological jaundice of the newborn2. Hemolytic states (blood-group incompatibility, hereditary spherocytosis)3. Infection (sepsis, syphilis, toxoplasmosis, cytomegalic inclusion disease, leptospirosis)4. Metabolic disturbances (galactosemia, cretinism, familial nonhemolytic jaundice)5. Inspissated-bile