RT Journal
A1 REED WA, KITTLE C
T1 OBservations on toxicity and use of antifoam a
JF A.M.A. Archives of Surgery
JO A.M.A. Archives of Surgery
YR 1959
FD February 1
VO 78
IS 2
SP 220
OP 225
DO 10.1001/archsurg.1959.04320020042008
UL http://dx.doi.org/10.1001/archsurg.1959.04320020042008
AB Shortly after beginning an investigation of long-term extracorporeal perfusion in dogs, we were impressed by the number of animals exhibiting postperfusion signs of central nervous system damage. These signs consisted of hemiplegia, skew deviation of the eyes, generalized ataxia, apathy, and apparent blindness. However, these changes were temporary, and by the ninth day after perfusion all such animals had returned to a presumed normal state. Although 16 of 17 consecutive animals perfused for two hours with a plastic disposable bubble-dispersion-type oxygenator * survived, neurologic changes were noted in 50% of the survivors. Gross examination of these animals' brains several weeks later at the time of elective killing disclosed focal areas of infarction. Similar areas of infarction were also noted in animals without clinical signs of central nervous system damage. The possibility of gas, fibrin, or Antifoam A emboli presented itself as a cause of these changes.14Although Antifoam substances have