RT Journal
A1 CUTOLO LC, KLEPPEL NH
T1 EFfect of perphenazine on postoperative emesis
JF A.M.A. Archives of Surgery
JO A.M.A. Archives of Surgery
YR 1959
FD October 1
VO 79
IS 4
SP 666
OP 669
DO 10.1001/archsurg.1959.04320100132022
UL http://dx.doi.org/10.1001/archsurg.1959.04320100132022
AB Emesis during the immediate postoperative period creates three major hazards: dehydration, electrolyte imbalance, and delayed alimentation. In addition the stress during retching and vomiting may disrupt fresh wounds, in particular those of the upper abdomen. It therefore seems desirable to seek medication which may offer alleviation of this rather common aftermath of systemic anesthesia and surgical therapy.Attempts to protect dogs against vomiting induced by apomorphine have shown that perphenazine has significantly greater antiemetic potency than other phenothiazines in current use.1,2 In the human, clinical experience reported by others3-5 supports its effectiveness. Prophylactic or therapeutic administration of perphenazine has been shown to be extremely effective when given parenterally before or after surgery to protect against postoperative emesis. In double-blind studies among surgical patients, perphenazine reduced the incidence of emesis from 18% to 6% in a series of 610 patients,6 from 48% to 25% in a series of