RT Journal
A1 CREECH O, Jr., KREMENTZ ET, RYAN RF, REEMTSMA K, WINBLAD JN, ELLIOTT JL
T1 THe treatment of cancer by perfusion
JF A.M.A. Archives of Surgery
JO A.M.A. Archives of Surgery
YR 1959
FD December 1
VO 79
IS 6
SP 963
OP 975
DO 10.1001/archsurg.1959.04320120105012
UL http://dx.doi.org/10.1001/archsurg.1959.04320120105012
AB Technique 
    Technique 
    Figure 3Figure 4Figure 5Figure 6Technique 
    Figure 7Figure 8Figure 9Figure 10Metastatic Melanoma 
    Fig. 11.—Before perfusion.Fig. 12.—Two years after perfusion.Case 1. 
    —A 77-year-old white man. In 1956 malignant melanoma removed from left foot, followed by groin dissection May, 1957: Appearance of multiple dermal metastases. June, 1957: Isolated perfusion with 120 mg. phenylalanine mustard (PAM) through common femoral artery.Fig. 13.—Original lesion.Fig. 14.—Metastasis, six weeks after perfusion.Fig. 15.—Metastasis, eight weeks after perfusion.Melanoma 
    Figure 16Case 2. 
    —1947: Small mole (malignant melanoma) removed from right medical lower leg. 1958: Local recurrence followed by multiple excisions. Treated with TSPA intra-arterially without improvement (Fig. 16, A). December, 1958: Common femoral artery perfusion with 130 mg. PAM (1.8 mg. per kilogram of body weight). January, 1959: Many lesions disappeared (Fig. 16, B).Figure 17Case 3. 
    —1957: Malignant melanoma with extensive metastases