RT Journal A1 Smith E, DeWeese MS T1 THe topical therapy of burns in children JF Archives of Surgery JO Archives of Surgery YR 1969 FD April 1 VO 98 IS 4 SP 462 OP 468 DO 10.1001/archsurg.1969.01340100094012 UL http://dx.doi.org/10.1001/archsurg.1969.01340100094012 AB The goal of therapy in the burn patient is to secure coverage of the injured area with the body's own tissues with or without operative assistance. Apart from the problems of initial resuscitation, burn wound sepsis constitutes the greatest threat to recovery. Studies of burn wound sepsis and the vascular destruction causing death of tissue have shown that topically applied antibacterial agents are more effective than those systemically administered.1,2 The agent must, however, be applied often enough and in such concentrations as to make it effective. Topical therapy does not include the application of a medically impregnated gauze which is not changed for several days. Topical agents in water-soluble bases can be used without any dressings or bandages. Daily hydrotherapy removes topical agent and dead tissue and a progressive debridement is achieved.During the four year period (1964-1967), 282 children, ranging in age from 1 month to 15 years,