RT Journal
A1 Rutherford RB, Boitnott JK, Donohoo JS, Margolis S, Sebor J, Zuidema GD
T1 PRoduction of nutritional cirrhosis in macacca mulatta monkeys
JF Archives of Surgery
JO Archives of Surgery
YR 1969
FD June 1
VO 98
IS 6
SP 720
OP 730
DO 10.1001/archsurg.1969.01340120068010
UL http://dx.doi.org/10.1001/archsurg.1969.01340120068010
AB Hepatic cirrhosis remains a major medical challenge both in regard to its pathogenesis and its treatment. The natural course of Laennec's cirrhosis, particularly its early development, does not lend itself to detailed clinical investigation, even if its victims were not so characteristically uncooperative. On the other hand, attempts to produce cirrhosis in experimental animals have either employed methods which produce a pathologic lesion significantly different from that encountered clinically (eg, carbon tetrachloride), or involved species whose livers exhibit important anatomical and physiological differences from man, or which are too small for detailed hemodynamic studies of portal hypertension and its modification by surgical shunting procedures. The production of nutritional cirrhosis in subhuman primates offers an opportunity to overcome some of these difficulties; preliminary reports by Wilgram1 and Gaisford and Zuidema2 of the production of an early "Laennec" type of cirrhosis in monkeys by a low protein, choline deficient diet