RT Journal
A1 Anderson MC, Toronto I, Needleman SB, Gramatica L
T1 ASsessment of methemalbumin as a diagnostic test for acute pancreatitis
JF Archives of Surgery
JO Archives of Surgery
YR 1969
FD June 1
VO 98
IS 6
SP 776
OP 780
DO 10.1001/archsurg.1969.01340120124023
UL http://dx.doi.org/10.1001/archsurg.1969.01340120124023
AB During the past five years several reports have indicated that methemalbumin appears in the peripheral blood of patients with severe hemorrhagic necrotizing pancreatitis.1,2 These reports, based upon a study of patients at the United Birmingham Hospitals in England, show that methemalbuminemia accurately reflects the severity of pancreatic inflammation and can be utilized to differentiate mild edematous pancreatitis, which has a low morbidity and mortality, from the more fulminating forms of the disease.The presence of methemalbumin in the peripheral circulation appears to be related to the formation of hematin from hemoglobin as enzymes act upon red blood cells (RBC) liberated into the inflamed area in and around the pancreas. A variety of hemolytic states also may produce methemalbuminemia; however, this occurs only when the amount of hemoglobin liberated during hemolysis is sufficient to exceed the binding capacity of haptoglobin in the patient's serum. Northam and associates1 report that