RT Journal
A1 Mabry CD, Read RC, Thompson BW, Williams G, White HJ
T1 IDentification of heparin resistance during cardiac and vascular surgery
JF Archives of Surgery
JO Archives of Surgery
YR 1979
FD February 1
VO 114
IS 2
SP 129
OP 134
DO 10.1001/archsurg.1979.01370260019002
UL http://dx.doi.org/10.1001/archsurg.1979.01370260019002
AB • An investigation of the response of the activated clotting time to systemic heparinization during cardiopulmonary bypass and peripheral vascular surgery was prompted by the death from clotting of a patient with endocarditis while undergoing valve replacement. The activated clotting time during cardiopulmonary bypass was thereafter maintained at 300 to 400 seconds. Consumption of heparin sodium, derived from an individual dose-response curve, was 0.01 to 3.86 units/kg/min. There was no correlation between initial heparin resistance and the subsequent rate of consumption. Some patients undergoing peripheral vascular surgery required additional heparin after an initial standard dose of 8,000 units so as to maintain their activated clotting time at twice the control values. These data are discussed in relation to previous articles, and recommendations are made for adequate intraoperative heparinization.(Arch Surg 114:129-134, 1979)