RT Journal A1 Harness JK, Ramsburg SR, Nishiyama RH, Thompson NW T1 Multiple adenomas of the parathyroids: Do they exist? JF Archives of Surgery JO Archives of Surgery YR 1979 FD April 1 VO 114 IS 4 SP 468 OP 474 DO 10.1001/archsurg.1979.01370280122018 UL http://dx.doi.org/10.1001/archsurg.1979.01370280122018 AB • Since Cope's original description of chief cell hyperplasia in 1958, there has been general agreement that this entity is the most common cause of multiple parathyroid enlargement. Whether or not multiple adenomas of the parathyroid glands ever occur has been seriously questioned. Criteria are proposed for defining the entity of multiple parathyroid adenomas in contrast with hyperplasia. With the use of these criteria, five patients with multiple adenomas were found in our last 300 cases of primary hyperparathyroidism.(Arch Surg 114:468-474, 1979)