RT Journal
A1 MacDonald A, Marble AE, Perkins JG
T1 HEpatic blood flow and metabolism
JF Archives of Surgery
JO Archives of Surgery
YR 1979
FD May 1
VO 114
IS 5
SP 616
OP 622
DO 10.1001/archsurg.1979.01370290066014
UL http://dx.doi.org/10.1001/archsurg.1979.01370290066014
AB • The relationship between liver blood flow and hepatic metabolism remains unclear. An animal model as well as a methodology that permits simultaneous assessment of both of these functions are proposed. Several fractions of inspired oxygen were used to produce arterial oxygen levels commonly seen in clinical practice; these ranged from hyperoxemia to established hypoxemia. Over this range there were no considerable changes in transhepatic blood flow, but there were considerable changes in hepatic metabolism as shown by measurements of the hepatic parenchymal pH, transhepatic oxygen consumption, and lactic acid use. Of these, the parenchymal pH seems to be the most sensitive indicator of metabolic events.(Arch Surg 114:616-622, 1979)