RT Journal A1 Gazitua R, Wilson K, Bistrian BR, Blackburn GL T1 FActors determining peripheral vein tolerance to amino acid infusions JF Archives of Surgery JO Archives of Surgery YR 1979 FD August 1 VO 114 IS 8 SP 897 OP 900 DO 10.1001/archsurg.1979.01370320029005 UL http://dx.doi.org/10.1001/archsurg.1979.01370320029005 AB • The tolerance of peripheral veins to intravenous infusions was evaluated. Of 83 infusions studied, 67 contained amino acids. Phlebitis occurred more commonly with the use of solutions that contained the amino acids. The important factors in the production of phlebitis by amino acid solutions were osmolarity, and the amount of potassium infused per day. Phlebitis was universal when osmolarity exceeded 600 mOsm. Other factors that promoted phlebitis were the presence of antibiotics and the size of the vein.(Arch Surg 114:897-900, 1979)