RT Journal
A1 Castillo MH, Doerr RJ, Paolini N, Jr, Cohen S, Goldrosen M
T1 HEpatectomy prolongs survival of mice with induced liver metastases
JF Archives of Surgery
JO Archives of Surgery
YR 1989
FD February 1
VO 124
IS 2
SP 167
OP 169
DO 10.1001/archsurg.1989.01410020037005
UL http://dx.doi.org/10.1001/archsurg.1989.01410020037005
AB • Resection of hepatic metastases from colorectal cancer has been shown to prolong survival in some patients. Whether this results from a reduction of tumor burden or is an indirect effect mediated by hepatectomy is questionable. Male C57BL/6Ros 8-week-old mice underwent ileocolic vein injection of a suspension of 0.3 mL of 2×105 viable liver-derived murine (MCA-38) colonic adenocarcinoma cells. This model produces hepatic metastases in all lobes of the liver. At 7,14, or 21 days after tumor injection, mice were randomized to receive either 42% resection of the liver or laparotomy alone. Survival in the animals with hepatectomy was significantly prolonged when the hepatectomy was performed 14 or 21 days after tumor injection.(Arch Surg 1989;124:167-169)