RT Journal
A1 Doerr R, Castillo M, Evans P, Paolini N, Goldrosen M, Cohen SA
T1 PArtial hepatectomy augments the liver's antitumor response
JF Archives of Surgery
JO Archives of Surgery
YR 1989
FD February 1
VO 124
IS 2
SP 170
OP 174
DO 10.1001/archsurg.1989.01410020040006
UL http://dx.doi.org/10.1001/archsurg.1989.01410020040006
AB • Despite adequate locoregional control, colorectal metastasis to the liver remains a significant cause of death. Resection of hepatic metastasis improves five-year survival 18% to 34%. A study of the impact of 40% partial hepatectomy on cytokine production in the liver was undertaken. Nonparenchymal liver cells (NPCs) were prepared by collagenase perfusion and metrizamide gradient from partially hepatectomized and laparotomized control C57BL/6Ros mice. Nonparenchymal cell from partially hepatectomized mice compared with laparotomized mice showed a twofold to threefold increase in interferon (IFN) activity. Both interferon alpha/beta and supernatants from cultured NPCs of partially hepatectomized mice suppressed the proliferation of liver-derived MCA-38 colon adenocarcinoma cells in vitro. This tumor has been shown to metastasize to the liver of C57BL/6Ros mice. The production of various cytokines by NPCs induced by partial hepatectomy may provide a possible antimetastatic mechanism.(Arch Surg 1989;124:170-174)