RT Journal
A1 Svartholm E, Bergqvist D, Hedner U, Ljungberg J, Haglund U
T1 THromboxane a2-receptor blockade and prostacyclin in porcine escherichia coli shock
JF Archives of Surgery
JO Archives of Surgery
YR 1989
FD June 1
VO 124
IS 6
SP 669
OP 672
DO 10.1001/archsurg.1989.01410060031006
UL http://dx.doi.org/10.1001/archsurg.1989.01410060031006
AB • Septic shock was induced by intravenous infusion of live Escherichia coli in pigs to investigate the influences on central hemodynamic, coagulation, and fibrinolytic reactions by a thromboxane A2 (T×A2)–receptor blocker (BM 13.177; n=6) and a prostacyclin analogue (iloprost or ZK 36374; n=7). The early pulmonary vasoconstriction following E coli infusion was attenuated, but not abolished, by BM 13.177. Only minor effects were seen after pretreatment with iloprost. Neither drug had any major effect on the coagulation and fibrinolytic activation. These results confirm that T×A2 is an important, but not the only, mediator of early pulmonary vascular response in porcine septicemia and that neither T×A2 nor prostacyclin is of major importance for the hemostatic reactions in this shock model.(Arch Surg 1989;124:669-672)