RT Journal
A1 probstfeld MR, O'Connell TX
T1 TReatment of locally recurrent breast carcinoma
JF Archives of Surgery
JO Archives of Surgery
YR 1989
FD October 1
VO 124
IS 10
SP 1127
OP 1130
DO 10.1001/archsurg.1989.01410100025005
UL http://dx.doi.org/10.1001/archsurg.1989.01410100025005
AB • Treatment of locally recurrent breast carcinoma remains a significant problem. The records of 106 patients with local chest wall recurrence were reviewed. Fifty-five percent eventually developed metastatic disease, while 45% remained free of systemic disease. Size of primary tumor (>2 cm), number of recurrences (multiple), and disease-free interval from primary surgery (<2 years) were all highly significant for the development of metastatic disease. Negative estrogen receptors also predicted bad prognosis. Both irradiation and surgery used alone had high local failure rates of 83% and 62%, respectively, but combination radiation-surgery treatment failed only in 25%. Combination radiation-surgery treatment should be considered in patients with local recurrence, but further prospective trials with more patients will be needed to prove its effectiveness. Patients with unfavorable prognostic factors should be considered for adjuvant chemotherapy.(Arch Surg. 1989;124:1127-1130)