TY  - JOUR
T1  - Long-term and perioperative corticosteroids in anastomotic leakage: A prospective study of 259 left-sided colorectal anastomoses
AU  - Slieker JC, Komen N, Mannaerts GH, et al
Y1  - 2012/05/01
N1  - 10.1001/archsurg.2011.1690
JO  - Archives of Surgery
SP  - 447
EP  - 452
VL  - 147
IS  - 5
N2  - Objective 
                  To determine the risk factors for symptomatic anastomotic leakage (AL) after colorectal resection.Design 
                  Review of records of patients who participated in the Analysis of Predictive Parameters for Evident Anastomotic Leakage study.Setting 
                  Eight health centers.Patients 
                  Two hundred fifty-nine patients who underwent left-sided colorectal anastomoses.Intervention 
                  Corticosteroids taken as long-term medication for underlying disease or perioperatively for the prevention of postoperative pulmonary complications.Main Outcome Measures 
                  Prospective evaluations for risk factors for symptomatic AL.Results 
                  In 23% of patients, a defunctioning stoma was constructed. The incidence of AL was 7.3%. The clinical course of patients with AL showed that in 21% of leaks, the drain indicated leakage; in the remaining patients, computed tomography or laparotomy resulted equally often in the detection of AL. In 50% of patients with AL, a Hartmann operation was needed. The incidence of AL was significantly higher in patients with pulmonary comorbidity (22.6% leakage), patients taking corticosteroids as long-term medication (50% leakage), and patients taking corticosteroids perioperatively (19% leakage). Perioperative corticosteroids were prescribed in 8% of patients for the prevention of postoperative pulmonary complications.Conclusions 
                  We found a significantly increased incidence of AL in patients treated with long-term corticosteroids and perioperative corticosteroids for pulmonary comorbidity. Therefore, we recommend that in this patient category, anastomoses should be protected by a diverting stoma or a Hartmann procedure should be considered to avoid AL.Trial Registration 
                  trialregister.nl Identifier: NTR1258
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.2011.1690
UR  - http://dx.doi.org/10.1001/archsurg.2011.1690
ER  -