TY  - JOUR
T1  - Massive transfusion: An evidence-based review of recent developments
AU  - Neal MD, Marsh A, Marino R, et al
Y1  - 2012/06/01
N1  - 10.1001/archsurg.2011.2212
JO  - Archives of Surgery
SP  - 563
EP  - 571
VL  - 147
IS  - 6
N2  - The design and implementation of massive transfusion protocols with ratio-based transfusion of blood and blood products are important and active areas of investigation. A significant yet controversial body of literature exists to support the use of hemostatic resuscitation in massive transfusion and new data to support the use of adjuncts, such as recombinant factor VIIa and tranexamic acid. We review the developments in massive transfusion research during the past 5 years, including protocol implementation, hemostatic resuscitation, the use of tranexamic acid, and goal-directed therapy for coagulopathy. Furthermore, we provide a level of evidence analysis of the data surrounding the use of component therapy and recombinant factor VIIa in massive transfusion, summary recommendations for the various agents of resuscitation, and new methods of goal-directed therapy.
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.2011.2212
UR  - http://dx.doi.org/10.1001/archsurg.2011.2212
ER  -