TY  - JOUR
T1  - Adamts13: Comment on “increased von willebrand factor to adamts13 ratio as a predictor of thrombotic complications following a major hepatectomy”
AU  - Kahn D, Krige JE
Y1  - 2012/10/01
N1  - 10.1001/archsurg.2012.1231
JO  - Archives of Surgery
SP  - 917
EP  - 918
VL  - 147
IS  - 10
N2  - 
The role of ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13) in hemostasis has been extensively documented in the hematology literature. In contrast, ADAMTS13 has hardly been noticed on the surgical radar. ADAMTS13 is a specific metalloproteinase that is responsible for cleaving the multimeric form of von Willebrand factor, thus preventing platelet aggregation and thrombus formation.1 Conversely, in the absence of ADAMTS13 activity, or with a profound deficiency of ADAMTS13, due to either genetic mutations or autoimmune inhibitors, ultralarge von Willebrand factor produced by vascular endothelial cells accumulate and induce widespread microvascular thrombosis characteristic of thrombotic thrombocytopenic purpura.

SN  - 0004-0010
M3  - doi: 10.1001/archsurg.2012.1231
UR  - http://dx.doi.org/10.1001/archsurg.2012.1231
ER  -