TY  - JOUR
T1  - Need for randomized clinical trials on intraoperative parathyroid hormone kinetics: Comment on “impact of race on intraoperative parathyroid hormone kinetics”
AU  - Ryan JA
Y1  - 2012/11/01
N1  - 10.1001/archsurg.2012.1496
JO  - Archives of Surgery
SP  - 1041
EP  - 1041
VL  - 147
IS  - 11
N2  - 
The use of intraoperative PTH testing to assure that no abnormally functioning parathyroids remain in the patient after removal of 1 parathyroid adenoma has slipped into widespread clinical use. In my opinion, this is unfortunate since the outcomes of this strategy have not been subjected to randomized clinical trials. Observational studies from the active, experienced, and world-renowned endocrine surgeons at the University of California, San Francisco have demonstrated less than 50% predictive success rate in patients with double parathyroid adenomas, a 13% false-negative rate with single parathyroid adenomas, a negative influence of hemolysis on the reliability of IOPTH measurement, and now the suggestion that race and BMI may impact PTH kinetics.1

SN  - 0004-0010
M3  - doi: 10.1001/archsurg.2012.1496
UR  - http://dx.doi.org/10.1001/archsurg.2012.1496
ER  -