TY  - JOUR
T1  - REsection with external beam and intraoperative radiotherapy for recurrent colon cancer
AU  - Pezner RD, Chu DJ, Wagman LD, Vora N, Wong JC, Shibata SI
Y1  - 1999/01/01
N1  - 10.1001/archsurg.134.1.63
JO  - Archives of Surgery
SP  - 63
EP  - 67
VL  - 134
IS  - 1
N2  - Objective 
    To review treatment outcomes for patients with locoregional recurrent colon cancer who underwent resection, intraoperative radiotherapy (IORT), and external beam radiotherapy (EBRT).Design 
    Retrospective study of patients treated between January 1990 and June 1994.Setting 
    Tertiary care cancer center.Patients 
    Eleven patients with bulky recurrent colon cancer extending to adjacent organs or structures signed informed consent forms to receive IORT.Intervention 
    Of 10 patients who underwent exploratory laparotomy, 5 had no metastatic disease and underwent resection, IORT, and EBRT. Complete resection was accomplished in 4 patients. Doses of IORT ranged from 13 to 20 Gy depending on residual tumor burden; EBRT was typically delivered postoperatively to a dose of 45 Gy.Main Outcome Measures 
    Survival and locoregional tumor control.Results 
    All 4 patients who underwent complete resection, IORT, and EBRT are alive without locoregional recurrence 53 to 77 months after treatment. Of these, only 1 patient developed distant metastases. The fifth patient, who had gross residual tumor, developed local recurrence 5 months after IORT. One patient developed an IORT complication—ureteral fibrosis leading to ipsilateral nephrectomy.Conclusion 
    Long-term disease-free survival can be achieved in selected patients with bulky regional recurrence of colon cancer with complete tumor resection, IORT, and EBRT.
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.134.1.63
UR  - http://dx.doi.org/10.1001/archsurg.134.1.63
ER  -