TY  - JOUR
T1  - Invited critique: Pathologic features of prognostic significance for adrenocortical carcinoma after curative resection
AU  - Saxe A
Y1  - 1999/02/01
N1  - 10.1001/archsurg.134.2.185
JO  - Archives of Surgery
SP  - 185
EP  - 185
VL  - 134
IS  - 2
N2  - 
Harrison et al have built on Brennan's long-standing interest in adrenocortical carcinoma, using the Memorial Sloan-Kettering Cancer Center's extensive experience and detailed database to compile a unique report. This series correlates histologic features of resected tumors with clinical outcome, but only in patients undergoing curative surgery. As they properly point out, other investigators have made the same correlation, but not in reports restricted to patients treated with curative surgery. Series "contaminated" by patients undergoing palliative surgery who received adjuvant therapy may obscure more subtle findings that should more properly influence the use of adjuvant therapy. Some may argue that the issue is moot without effective adjuvant agents. Although mitotane has been almost uniformly disappointing, there is hope that taxanes may be effective.

SN  - 0004-0010
M3  - doi: 10.1001/archsurg.134.2.185
UR  - http://dx.doi.org/10.1001/archsurg.134.2.185
ER  -