TY  - JOUR
T1  - LYmphangiosis as a predictor of outcome in patients with primary diffusely infiltrative adenocarcinoma of the colon and rectum
AU  - Tang R, Wang J, Tsao K, Ho Y
Y1  - 1999/02/01
N1  - 10.1001/archsurg.134.2.157
JO  - Archives of Surgery
SP  - 157
EP  - 160
VL  - 134
IS  - 2
N2  - Objective 
    To investigate the relationships between outcome and clinicopathological factors, DNA flow cytometrical characteristics, and postoperative adjuvant therapy in patients with primary diffusely infiltrative colorectal adenocarcinoma.Design 
    Inception cohort study.Setting 
    A medical center that offers a mixture of primary, secondary, and tertiary care services.Patients 
    Among 7035 patients undergoing resection of primary colorectal adenocarcinoma from 1980 to 1996, 37 patients with a pathological diagnosis of primary diffusely infiltrative tumor were selected. All patients had received regular follow-up until February 28, 1998, or until death.Main Outcome Measures 
    Cancer-specific survival compared by log-rank test and Cox regression model.Results 
    Univariate analyses revealed tumor stage (stages II-III vs stage IV, P=.01) and severity of lymphangiosis (absent/mild vs moderate/severe, P=.04) were significant in predicting outcome. A proliferative index of greater than 20% was insignificant (P=.08) in predicting outcome. In a Cox regression model, TNM stage and lymphangiosis were independently correlated with a worse outcome. When compared with tumors having less severe lymphangiosis, the odds ratio of death due to cancer in cases of tumors with moderate to severe lymphangiosis was 2.4 (95% confidence interval, 1.0-5.6; P=.05).Conclusion 
    Lymphangiosis and TNM stage were independently predictive of outcome in patients with primary diffusely infiltrative colorectal cancer.
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.134.2.157
UR  - http://dx.doi.org/10.1001/archsurg.134.2.157
ER  -