TY  - JOUR
T1  - THe acute inflammatory response and its regulation
AU  - Ward PA, Lentsch AB
Y1  - 1999/06/01
N1  - 10.1001/archsurg.134.6.666
JO  - Archives of Surgery
SP  - 666
EP  - 669
VL  - 134
IS  - 6
N2  - The acute inflammatory response is composed of an elaborate cascade of both proinflammatory and anti-inflammatory mediators. The balance between these mediators often determines the outcome after injury. In clincal scenarios, such as trauma or sepsis, there is often unregulated production of proinflammatory mediators that can cause multiple organ failure. Further understanding of the endogenous mechanisms that control the inflammatory response is needed to facilitate development of therapeutic options. In this review, we discuss the current knowledge of the mechanisms leading to development of acute inflammatory injury as well as the factors that regulate this response.
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.134.6.666
UR  - http://dx.doi.org/10.1001/archsurg.134.6.666
ER  -