TY  - JOUR
T1  - IMportance of surgical resection in the successful management of soft tissue sarcoma
AU  - Flugstad DL, Wilke CP, McNutt MA, Welk RA, Hart MJ, McQuinn WC
Y1  - 1999/08/01
N1  - 10.1001/archsurg.134.8.856
JO  - Archives of Surgery
SP  - 856
EP  - 862
VL  - 134
IS  - 8
N2  - Hypothesis 
    A systemic disease-free state necessitates a local disease-free state. This cannot be accomplished without a properly performed resection by an experienced surgical team. Successful local management of soft tissue sarcoma (STS) may lead to improved disease-free survival. An STS treatment protocol using wide local excision followed by radiation therapy is effective in achieving local tumor control and survival similar to that of multiple-modality regimens, but with lower morbidity.Design 
    Retrospective cohort review (August 1, 1987, to May 6, 1998).Setting 
    Referral to a single musculoskeletal oncologic surgeon, with surgery performed at a tertiary care medical center in a large urban area.Patients 
    Ninety patients with STS of the trunk or extremities.Interventions 
    Preoperative evaluation included surveillance computed tomographic scan of the chest, magnetic resonance imaging of primary site to assess tumor extent and to plan the surgical approach, and angiography if vascular bypass was proposed. Wide local excision of tumor was performed, with concomitant vascular bypass and/or complex plastic reconstruction as needed. Postoperative radiation therapy was given in most patients. Adjuvant chemotherapy was used selectively.Main Outcome Measures 
    Morbidity, local recurrence rates, and survival.Results 
    Histologically negative margins were obtained in 89 (99%) of 90 patients; 86 (96%) remained free of local disease at follow-up. Five patients died of systemic metastatic disease.Conclusion 
    Excellent local control obtained with aggressive, appropriate surgery followed by radiation therapy in most patients and chemotherapy in only selective high-risk patients leads to excellent survival, with low morbidity and good functional outcome.
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.134.8.856
UR  - http://dx.doi.org/10.1001/archsurg.134.8.856
ER  -