TY  - JOUR
T1  - HYperbaric oxygen for treating wounds—invited critique
AU  - Yang GP, Longaker MT
Y1  - 2003/03/01
N1  - 10.1001/archsurg.138.3.280
JO  - Archives of Surgery
SP  - 280
EP  - 280
VL  - 138
IS  - 3
N2  - 
This study highlights an important point in the translation of basic scientific knowledge to actual bedside treatment. A number of in vitro studies have indicated that cells involved in the process of wound repair are dysfunctional when placed in a hypoxic environment. The direct translation of these data was that oxygen delivery to poorly healing wounds was compromised and that improved oxygen delivery might allow those wounds to heal. An added corollary is that in a disease process where a lack of oxygen is required for progression, ie, necrotizing infections, the use of HBO might limit spread and aid recovery. However, Wang et al has clearly demonstrated that there are no clear guidelines for HBO therapy.

SN  - 0004-0010
M3  - doi: 10.1001/archsurg.138.3.280
UR  - http://dx.doi.org/10.1001/archsurg.138.3.280
ER  -