TY  - JOUR
T1  - GAstric surgery as a long-term risk factor for malignant lesions of the larynx
AU  - Cianci R, Galli J, Agostino S, et al
Y1  - 2003/07/01
N1  - 10.1001/archsurg.138.7.751
JO  - Archives of Surgery
SP  - 751
EP  - 754
VL  - 138
IS  - 7
N2  - Background 
    Duodenogastroesophageal reflux is common after total or partial gastrectomy. No data are available on the effect of duodenal reflux on the larynx.Hypothesis 
    Premalignant or malignant changes occur more frequently among subjects with gastric surgery.Design 
    Historical cohort study.Setting 
    Outpatient setting for upper endoscopy.Patients 
    Ninety-three subjects who had undergone gastric resection at least 5 years previously, and 93 matched dyspeptic individuals who did not undergo gastric surgery.Intervention 
    Clinical histories of all patients were obtained and recorded. All subjects underwent an otolaryngologic evaluation.Results 
    Of 93 patients with gastric resection, 7 patients had current or previous laryngeal malignancies or current precancerous mucosal changes. In the control group, 1 subject had a leukoplakia on the vocal cord. The adjusted odds ratio (having included sex, age, and alcohol [yes or no] and smoking [yes or no] history in the regression model) was 9.88 (95% confidence interval, 1.01-97.31; likelihood ratio χ2 = 28.77; P<.001). Furthermore, there was a significant increased prevalence of benign laryngeal lesions in patients with gastric resection vs the control group.Conclusions 
    The risk of developing laryngeal malignancies is higher for patients with gastric resection. A periodic otolaryngologic evaluation in subjects with gastric surgery may contribute to early diagnosis of laryngeal disorders.
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.138.7.751
UR  - http://dx.doi.org/10.1001/archsurg.138.7.751
ER  -