TY  - JOUR
T1  - RNa silencing in surgical disease—invited critique
AU  - Lowry SF
Y1  - 2003/10/01
N1  - 10.1001/archsurg.138.10.1148
JO  - Archives of Surgery
SP  - 1148
EP  - 1148
VL  - 138
IS  - 10
N2  - 
It has been known for some time that small RNA sequences could interfere (interfering RNA [iRNA]) with gene expression. This influence assumed new importance with the identification of an enzyme, the so-called dicer, that produces small RNAs from dsRNA. These small RNAs come in at least 2 flavors: siRNAs and micro-RNAs. Both species probably participate in iRNA in concert with an enzyme complex (RISC) by degrading complementary mRNAs. Such control of gene expression and protein production also may protect cells from adverse viral influences on gene transcription and chromatin stability.

SN  - 0004-0010
M3  - doi: 10.1001/archsurg.138.10.1148
UR  - http://dx.doi.org/10.1001/archsurg.138.10.1148
ER  -