TY  - JOUR
T1  - PRetransplantation soluble adhesion molecule expression predicts outcome after living donor renal transplantation
AU  - Perez RV, Huang CQ, Johnson JR, et al
Y1  - 2003/10/01
N1  - 10.1001/archsurg.138.10.1113
JO  - Archives of Surgery
SP  - 1113
EP  - 1120
VL  - 138
IS  - 10
N2  - Hypothesis 
    Occult pretransplantation systemic inflammation will identify patients at risk for poor outcomes after renal transplantation.Design 
    Retrospective cohort study. Adhesion molecule levels were measured in pretransplantation serum samples from 86 recipients. Univariate and multivariate analyses were conducted to assess a possible correlation between serum adhesion molecule level and outcome.Setting 
    University referral center.Main Outcome Measures 
    Allograft rejection and survival.Results 
    Patients with low levels of vascular cell adhesion molecule 1 had less graft rejection (P = .007). Low levels of vascular cell adhesion molecule 1 independently predicted decreased rejection (relative risk, 0.17; P = .01), and high levels of vascular cell adhesion molecule 1 independently predicted graft loss (relative risk, 3.83; P = .02). Similar correlations were observed for intercellular adhesion molecule 1.Conclusions 
    Decreased pretransplantation adhesion molecule expression correlates with less rejection, and increased levels correlate with graft loss. Assessment of pretransplantation inflammatory status may be useful in optimizing immunosuppression therapy.
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.138.10.1113
UR  - http://dx.doi.org/10.1001/archsurg.138.10.1113
ER  -