TY  - JOUR
T1  - EXpression of transforming growth factor β1 in patients with and without previous abdominal surgery
AU  - Hobson KG, DeWing M, Ho HS, Wolfe BM, Cho K, Greenhalgh DG
Y1  - 2003/11/01
N1  - 10.1001/archsurg.138.11.1249
JO  - Archives of Surgery
SP  - 1249
EP  - 1252
VL  - 138
IS  - 11
N2  - Hypothesis 
    Transforming growth factor β1 (TGF-β1) plays an important role in the formation of adhesions after abdominal operations.Design 
    Prospective, observational study.Setting 
    University-based, tertiary referral center.Patients 
    Patients undergoing elective open abdominal operations were recruited and divided into 2 groups. Twenty-two patients with a history of abdominal surgery were designated as study patients, and 10 patients with no history of abdominal surgery served as controls.Interventions 
    Samples of normal peritoneum, peritoneal scar tissues, and serum were obtained from all patients at the time of surgery.Main Outcome Measures 
    Samples were assayed for total TGF-β1 expression using an enzyme-linked immunosorbent assay.Results 
    Scar tissues expressed significantly greater amounts of TGF-β1 (0.47 pg/µL) compared with normal peritoneal tissue from both study patients (0.29 pg/µL; P = .03) and controls (0.17 pg/µL; P = .002). Serum TGF-β1 levels were also higher in study patients (1.71 pg/µL) compared with controls (1.22 pg/µL; P = .02). Neither adhesion nor serum TGF-β1 expression correlated with time since last operation, total number of previous operations, or severity of intra-abdominal adhesions.Conclusion 
    These results suggest that TGF-β1 may play an important role in human peritoneal adhesion formation.
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.138.11.1249
UR  - http://dx.doi.org/10.1001/archsurg.138.11.1249
ER  -