TY  - JOUR
T1  - Adjuvant chemoradiotherapy in patients with stage iii or iv radically resected gastric cancer: A pilot study
AU  - Orditura M, De Vita F, Muto P, et al
Y1  - 2010/03/01
N1  - 10.1001/archsurg.2010.2
JO  - Archives of Surgery
SP  - 233
EP  - 238
VL  - 145
IS  - 3
N2  - Background 
    Adjuvant chemoradiotherapy does not represent the standard of care in patients with resected high-risk gastric cancer; however, results from phase 2 and randomized trials suggest improvement in overall survival. We assessed the feasibility and toxic effects of chemoradiotherapy as adjuvant treatment in locally advanced gastric cancer.Design 
    Pilot study.Setting 
    University hospital.Patients 
    Twenty-nine patients with T4N+ or any TN23 gastric cancer previously treated with potentially curative surgery were enrolled. All of the patients received combined adjuvant chemotherapy with FOLFOX-4 (ie, a combination of folinic acid [leucovorin], fluorouracil, and oxaliplatin [Eloxatin]) for 8 cycles and concomitant radiotherapy (45 Gy in 25 daily fractions over 5 weeks). Radiotherapy was begun after the first 2 cycles of FOLFOX-4, which was reduced by 25% during the period of concomitant radiotherapy.Main Outcome Measures 
    Treatment toxic effects according to the National Cancer Institute–Common Toxicity Criteria classification, overall and disease-free survival rates, and identification of prognostic indicators.Results 
    All of the patients completed treatment. Severe hematologic and gastrointestinal toxic effects occurred in 10% and 33%, respectively. No acute hepatic or renal toxic effects were observed; 1 patient experienced severe neurotoxicity. Disease-free and overall survival rates at 1, 2, and 3 years were 79%, 35%, and 35% and 85%, 62.6%, and 50.1%, respectively, and were shown to be substantially better than those observed in untreated patients. Long-term outcome was related to TNM stage, basal serum tumor marker level, and, particularly, lymph node ratio.Conclusion 
    A multimodal approach with FOLFOX-4 and radiotherapy is feasible and effective for the treatment of patients with resected high-risk gastric cancer.
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.2010.2
UR  - http://dx.doi.org/10.1001/archsurg.2010.2
ER  -