TY  - JOUR
T1  - PArenteral fish oil monotherapy in the management of patients with parenteral nutrition–associated liver disease
AU  - de Meijer VE, Gura KM, Meisel JA, Le HD, Puder M
Y1  - 2010/06/01
N1  - 10.1001/archsurg.2010.80
JO  - Archives of Surgery
SP  - 547
EP  - 551
VL  - 145
IS  - 6
N2  - Objectives 
    To update knowledge on the management of parenteral nutrition–associated liver disease (PNALD) and to review the clinical data on the use of parenteral fish oil for reversal of PNALD.Data Sources 
    A literature review was conducted by searching the MEDLINE database (May 1, 2009) using the keywords parenteral nutrition–associated liver disease, fish oil, omega-3, Omegaven, and lipid emulsion.Study Selection 
    All articles reporting clinical cases with the use of parenteral fish oil for management of PNALD.Data Extraction 
    Three reviewers independently analyzed the epidemiological, clinical, and treatment data of the articles.Data Synthesis 
    Six case reports (10 patients) and 2 cohort studies (12 and 18 patients) were analyzed.Conclusions 
    Fish oil–derived emulsions have been demonstrated to reverse preexisting PNALD and to prevent and treat essential fatty acid deficiency. Its ability to prevent PNALD is currently under investigation. Although the mechanism has yet to be fully understood, the advantages of fish oil–based lipid emulsions over soybean oil–based lipid emulsions seen to date suggest that fish oil–based emulsions would be better suited for use in long-term parenteral nutrition.
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.2010.80
UR  - http://dx.doi.org/10.1001/archsurg.2010.80
ER  -