TY  - JOUR
T1  - NEuronal differentiation of human adipose tissue–derived stem cells for peripheral nerve regeneration in vivo
AU  - Scholz T, Sumarto A, Krichevsky A, Evans GD
Y1  - 2011/06/01
N1  - 10.1001/archsurg.2011.148
JO  - Archives of Surgery
SP  - 666
EP  - 674
VL  - 146
IS  - 6
N2  - 
Nerve lesions in the peripheral nervous system are common injuries that affect 2.8% of trauma patients and often result in permanent disability.1- 2 If primary repair of nerve lesions cannot be achieved, the gold standard is the autologous nerve graft. However, this treatment has drawbacks of suboptimal functional recovery rates, limited graft tissue supply, loss of function at the donor site, and donor site morbidity.3- 4 A promising alternative to direct suturing or interposing of an autograft is a tissue-engineered nerve construct that bridges the nerve gap and facilitates the complex interplay between cells, growth factors, and extracellular matrix required for regeneration. Studies have demonstrated that embryonic stem cells and adult neural stem cells isolated from the brain and spinal cord could differentiate into neurons after implantation into an injured nerve, but ethical and logistical concerns have hindered their therapeutic use until now.4 Some recent studies have described mesenchymal bone marrow–derived stem cells (BMSCs) that exhibited the capacity to differentiate into many mesodermal cell types, including neural cell lineages.5- 10 Although these are more plentiful and more accessible than neural progenitor cells, bone marrow aspiration incurs donor site morbidity and often yields limited numbers of cells.11

SN  - 0004-0010
M3  - doi: 10.1001/archsurg.2011.148
UR  - http://dx.doi.org/10.1001/archsurg.2011.148
ER  -