TY  - JOUR
T1  - THe surgical management of functional adrenal hypercorticism
AU  - OVERTON RC, OVERSTREET JW, FORD RV
Y1  - 1959/11/01
N1  - 10.1001/archsurg.1959.04320110093015
JO  - A.M.A. Archives of Surgery
SP  - 791
EP  - 798
VL  - 79
IS  - 5
N2  - The improvement of laboratory techniques for diagnosis of abnormal adrenal states has permitted the internist to present to the surgeon a greater variety of patients as possible candidates for treatment of overactivity of the adrenal cortex. The time-honored designation of "Cushing's syndrome" need not apply to this expanded group of patients since they may be considered to be in an earlier phase of "hyperadrenocorticism." Observations of a small group of these patients who have been subjected to total bilateral adrenalectomy constitute this report.We believe that hyperadrenocorticism is initially a cyclical disease, which rarely is self-limited and most commonly is progressive. Further, if repeated observations are made on patients suspected clinically of having functional hypercorticism, the patients will persistently present these laboratory evidences (corticotropin-induced hyperresponsiveness), and the clinician is justified in recommending definitive therapy. In the absence of a chemotherapeutic agent to inhibit adrenocortical function (without prohibitive toxicity), one must
SN  - 0096-6908
M3  - doi: 10.1001/archsurg.1959.04320110093015
UR  - http://dx.doi.org/10.1001/archsurg.1959.04320110093015
ER  -