TY - JOUR T1 - THe treatment of cancer by perfusion AU - CREECH O, Jr., KREMENTZ ET, RYAN RF, REEMTSMA K, WINBLAD JN, ELLIOTT JL Y1 - 1959/12/01 N1 - 10.1001/archsurg.1959.04320120105012 JO - A.M.A. Archives of Surgery SP - 963 EP - 975 VL - 79 IS - 6 N2 - Technique  Technique  Figure 3Figure 4Figure 5Figure 6Technique  Figure 7Figure 8Figure 9Figure 10Metastatic Melanoma  Fig. 11.—Before perfusion.Fig. 12.—Two years after perfusion.Case 1.  —A 77-year-old white man. In 1956 malignant melanoma removed from left foot, followed by groin dissection May, 1957: Appearance of multiple dermal metastases. June, 1957: Isolated perfusion with 120 mg. phenylalanine mustard (PAM) through common femoral artery.Fig. 13.—Original lesion.Fig. 14.—Metastasis, six weeks after perfusion.Fig. 15.—Metastasis, eight weeks after perfusion.Melanoma  Figure 16Case 2.  —1947: Small mole (malignant melanoma) removed from right medical lower leg. 1958: Local recurrence followed by multiple excisions. Treated with TSPA intra-arterially without improvement (Fig. 16, A). December, 1958: Common femoral artery perfusion with 130 mg. PAM (1.8 mg. per kilogram of body weight). January, 1959: Many lesions disappeared (Fig. 16, B).Figure 17Case 3.  —1957: Malignant melanoma with extensive metastases SN - 0096-6908 M3 - doi: 10.1001/archsurg.1959.04320120105012 UR - http://dx.doi.org/10.1001/archsurg.1959.04320120105012 ER -