TY  - JOUR
T1  - HIstidine decarboxylase inhibitors and second-set allograft survival
AU  - Moore TC
Y1  - 1969/10/01
N1  - 10.1001/archsurg.1969.01340160050012
JO  - Archives of Surgery
SP  - 470
EP  - 473
VL  - 99
IS  - 4
N2  - A 33-fold increase in histidine decarboxylase (HDC) activity of allografted rat skin has been found during rejection.1 Full-thickness grafts were carried out from inbred Lewis to inbred PA rats and the peak elevation in HDC activity occurred ten days after grafting. No such change occurred in autografted skin.An increase in HDC activity also has been encountered in rat spleen, but not in intestinal-tract Peyer's patches lymphoid tissue, after skin allografting across this same histocompatibility barrier according to T.C. Moore and R.W. Schayer (unpublished data). These observations, and the finding of an increase in 24-hour urinary histamine excretion in the rat during skin allograft rejection,2 suggest an involvement of intracellular histamine formation from increased HDC activity in the biologic mechanism of allograft rejection. Kahlson3 has found 24-hour urinary histamine excretion to be a useful means of monitoring intracellular histamine formation from increased HDC activity.Histamine is formed
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.1969.01340160050012
UR  - http://dx.doi.org/10.1001/archsurg.1969.01340160050012
ER  -