TY  - JOUR
T1  - ERythropoietin release after aortic coarctation in the baboon
AU  - Murphy GP, Groenewald JH, Mirand EA, van Zyl JW
Y1  - 1969/10/01
N1  - 10.1001/archsurg.1969.01340160104024
JO  - Archives of Surgery
SP  - 524
EP  - 528
VL  - 99
IS  - 4
N2  - There has been considerable disagreement as to whether the changes in blood pressure observed in coarctation of the aorta can be explained solely by the mechanical effects of the lesion.1 Barcroft,2,3 Brotchner,4 and Page5 have previously shown that after acute aortic constriction in dogs, there is an immediate elevation of the blood pressure which is proportional to the amount of obstruction to the blood flow. However, as has long been appreciated, the results in many experimental situations are not strictly analogous to human coarctation.1,5 Clinical studies of renal function before and after operative correction of long-standing aortic coarctation have failed to show consistent or uniform improvement in renal hemodynamics.1,6,7 The relationship of renal ischemia to the observed hypertension has also not been completely accepted.15 Others have suggested, previously, that renin is released in response to the clinical or experimental coarctation.8-10 The resultant
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.1969.01340160104024
UR  - http://dx.doi.org/10.1001/archsurg.1969.01340160104024
ER  -