TY  - JOUR
T1  - CAncer of the parathyroid glands
AU  - van Heerden JA, Weiland LH, ReMine WH, Walls JT, Purnell DC
Y1  - 1979/04/01
N1  - 10.1001/archsurg.1979.01370280129019
JO  - Archives of Surgery
SP  - 475
EP  - 480
VL  - 114
IS  - 4
N2  - • Hyperfunctioning parathyroid carcinoma is a relatively rare endocrine tumor, accounting for approximately 1% of all cases of primary hyperparathyroidism. The diagnosis is suspected when the tumor is large, parathyroid hormone (iPTH) levels are high, and a palpable tumor is present in the neck. Patients who have recurrence of hyperparathyroidism several months after surgical treatment should be suspected of having a recurrent or persistent parathyroid carcinoma. At operation, a large invasive tumor is usually found. The fibrous, inflammatory-like reaction is the most characteristic indication of malignancy. Even in tumors with minimal invasiveness, the possibility of a carcinoma should be considered if the tumor has mitotic activity and a monotonous instead of a pleomorphic cellular population. If the surgeon can recognize the possibility of parathyroid malignancy and adequately treat the patient during the initial operation, more gratifying results should be obtained.(Arch Surg 114:475-480, 1979)
SN  - 0004-0010
M3  - doi: 10.1001/archsurg.1979.01370280129019
UR  - http://dx.doi.org/10.1001/archsurg.1979.01370280129019
ER  -